' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 15 Researches
7.4
USERS' SCORE
Excellent
Based on 5 Reviews
9.3
Supplement Facts
Serving Size: 1 Teaspoon (5 ml)
Amount Per Serving
%DV
Calories
40
Total Fat
4.5 g
6%**
Saturated Fat
0.5 g
3%**
Cholesterol
15 mg
5%
Vitamin A (from cod liver oil and retinyl palmitate)
255 mcg RAE(850 IU)
28%
Vitamin D (from cod liver oil and cholecalciferol)
10 mcg (400 IU)
50%
Vitamin E (as d-alpha tocopherol)
6.7 mg
45%
Norwegian Cod Liver Oil
4.6 g
†
Total Omega-3 Fatty Acids*
1,100 mg
†
DHA (Docosahexaenoic Acid)*
500 mg
†
EPA (Eicosapentaenoic Acid)*
370 mg
†
DPA (Docosapentaenoic Acid)*
50 mg
†
Top Medical Research Studies
8
Eicosapentaenoic acid benefits MS
The therapeutic effect of PEGlated nanoliposome of pistachio unsaturated oils and its efficacy to attenuate inflammation in multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial phase I.
Directly addresses eicosapentaenoic acid
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore the effects of PEGlated nanoliposome of pistachio unsaturated oils on inflammation in multiple sclerosis (MS). During the study, we treated MS patients with these nanoliposomes enriched with eicosapentaenoic acid, a type of omega-3 fatty acid known for its potential health benefits.
After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.
Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.
Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
Read More
9
Eicosapentaenoic Acid aids autoimmunity
ω-3 polyunsaturated fatty acid alleviates systemic lupus erythematosus by suppressing autoimmunity in a murine model.
Highly relevant autoimmune research
We explored the effect of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on systemic lupus erythematosus (SLE), a complex autoimmune disease that causes widespread inflammation in the body. In a carefully designed study using a mouse model of SLE, we discovered that dietary supplementation with EPA-rich fish oil significantly improved various autoimmune symptoms.
Our findings revealed that, after treatment, the mice showed reductions in fluid accumulation, abnormal tissue growth, and levels of certain autoantibodies in their blood. Notably, EPA also led to improvements in kidney health, evidenced by reduced protein levels in urine and decreased inflammation in kidney tissues.
Delving into the mechanisms, we found that EPA influenced how immune cells, particularly B cells, develop. It helped in reducing the overall number of B cells, which are often overactive in autoimmune diseases. Furthermore, EPA encouraged the production of an anti-inflammatory cytokine called IL-10. This is significant because IL-10 plays a crucial role in controlling immune responses and curbing inflammation.
Overall, our research suggests that integrating omega-3 fatty acids like EPA into diets could serve as a promising approach to managing autoimmune conditions, such as SLE. By balancing the intake of omega-3 and omega-6 fatty acids, we may better control the onset and severity of this challenging disease.
Our findings revealed that, after treatment, the mice showed reductions in fluid accumulation, abnormal tissue growth, and levels of certain autoantibodies in their blood. Notably, EPA also led to improvements in kidney health, evidenced by reduced protein levels in urine and decreased inflammation in kidney tissues.
Delving into the mechanisms, we found that EPA influenced how immune cells, particularly B cells, develop. It helped in reducing the overall number of B cells, which are often overactive in autoimmune diseases. Furthermore, EPA encouraged the production of an anti-inflammatory cytokine called IL-10. This is significant because IL-10 plays a crucial role in controlling immune responses and curbing inflammation.
Overall, our research suggests that integrating omega-3 fatty acids like EPA into diets could serve as a promising approach to managing autoimmune conditions, such as SLE. By balancing the intake of omega-3 and omega-6 fatty acids, we may better control the onset and severity of this challenging disease.
Read More
9
Eicosapentaenoic acid aids lupus management
Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity.
Highly relevant to autoimmune research
We sought to understand how dietary fatty acids, specifically eicosapentaenoic acid (EPA), influence autoimmune diseases like lupus. Through our research on both drug-induced and spontaneous mouse models of lupus, we observed that supplementing with EPA significantly eased symptoms associated with the disease.
Some of the notable improvements included reduced autoantibody production and diminished immunocomplex deposits in the kidneys. Our examinations through lipidomic and membrane dynamics analyses revealed that EPA changes the lipid composition and fluidity of B cell membranes. This adjustment appears to restrict the differentiation of B cells into plasma cells that produce harmful autoantibodies.
Overall, our findings indicate a promising new pathway by which fatty acids like EPA can potentially help manage autoimmunity. This suggests that EPA supplementation might serve as a beneficial treatment option for individuals with lupus.
Some of the notable improvements included reduced autoantibody production and diminished immunocomplex deposits in the kidneys. Our examinations through lipidomic and membrane dynamics analyses revealed that EPA changes the lipid composition and fluidity of B cell membranes. This adjustment appears to restrict the differentiation of B cells into plasma cells that produce harmful autoantibodies.
Overall, our findings indicate a promising new pathway by which fatty acids like EPA can potentially help manage autoimmunity. This suggests that EPA supplementation might serve as a beneficial treatment option for individuals with lupus.
Read More
Most Useful Reviews
9.5
Highly recommend fish oil
I have tried various fish oil brands, and this one is by far the best. Its effects are noticeable quickly, and I have ordered it again. I highly recommend this product!
Read More
9.5
Improved wellbeing
Honestly, I find it excellent. I started using it due to my autoimmune disorder, which caused me health issues. It's helped me feel better and regain my appetite. I will continue to buy it until I am completely healed.
Read More
9.5
No allergic reactions
This fish oil has been great for my allergic child with an autoimmune disorder; there were no rashes, and he took it without difficulty.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 15 Researches
7.4
9
Eicosapentaenoic Acid aids autoimmunity
ω-3 polyunsaturated fatty acid alleviates systemic lupus erythematosus by suppressing autoimmunity in a murine model.
Highly relevant autoimmune research
We explored the effect of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on systemic lupus erythematosus (SLE), a complex autoimmune disease that causes widespread inflammation in the body. In a carefully designed study using a mouse model of SLE, we discovered that dietary supplementation with EPA-rich fish oil significantly improved various autoimmune symptoms.
Our findings revealed that, after treatment, the mice showed reductions in fluid accumulation, abnormal tissue growth, and levels of certain autoantibodies in their blood. Notably, EPA also led to improvements in kidney health, evidenced by reduced protein levels in urine and decreased inflammation in kidney tissues.
Delving into the mechanisms, we found that EPA influenced how immune cells, particularly B cells, develop. It helped in reducing the overall number of B cells, which are often overactive in autoimmune diseases. Furthermore, EPA encouraged the production of an anti-inflammatory cytokine called IL-10. This is significant because IL-10 plays a crucial role in controlling immune responses and curbing inflammation.
Overall, our research suggests that integrating omega-3 fatty acids like EPA into diets could serve as a promising approach to managing autoimmune conditions, such as SLE. By balancing the intake of omega-3 and omega-6 fatty acids, we may better control the onset and severity of this challenging disease.
Our findings revealed that, after treatment, the mice showed reductions in fluid accumulation, abnormal tissue growth, and levels of certain autoantibodies in their blood. Notably, EPA also led to improvements in kidney health, evidenced by reduced protein levels in urine and decreased inflammation in kidney tissues.
Delving into the mechanisms, we found that EPA influenced how immune cells, particularly B cells, develop. It helped in reducing the overall number of B cells, which are often overactive in autoimmune diseases. Furthermore, EPA encouraged the production of an anti-inflammatory cytokine called IL-10. This is significant because IL-10 plays a crucial role in controlling immune responses and curbing inflammation.
Overall, our research suggests that integrating omega-3 fatty acids like EPA into diets could serve as a promising approach to managing autoimmune conditions, such as SLE. By balancing the intake of omega-3 and omega-6 fatty acids, we may better control the onset and severity of this challenging disease.
Read More
9
Combination therapy shows promise
Omega-3 Polyunsaturated Fatty Acid: A Pharmaco-Nutraceutical Approach to Improve the Responsiveness to Ursodeoxycholic Acid.
Moderate relevance to autoimmune treatment
We set out to understand if adding eicosapentaenoic acid (EPA) to ursodeoxycholic acid (UDCA) could improve outcomes for patients with autoimmune disorders and cholestatic liver diseases. By evaluating how this combination affects key factors like bile acid management, cell apoptosis, and inflammation, we aimed to see if EPA could bolster the effects of UDCA, especially in patients who typically do not respond well to this treatment.
Interestingly, we found that when EPA was combined with a lower dose of UDCA, the results were quite appealing. The combination helped reduce the expression of certain inflammatory genes and showed a notable decrease in cell damage caused by bile acids, even when compared to higher doses of UDCA alone. This means that with EPA, we could potentially achieve better therapeutic outcomes without escalating the drug dosage.
Our findings suggest that incorporating EPA alongside UDCA not only enhances the benefits but could also widen the therapeutic window for patients struggling with liver issues linked to autoimmune disorders. This exciting pharmaco-nutraceutical approach may pave the way for more effective treatments in the future.
Interestingly, we found that when EPA was combined with a lower dose of UDCA, the results were quite appealing. The combination helped reduce the expression of certain inflammatory genes and showed a notable decrease in cell damage caused by bile acids, even when compared to higher doses of UDCA alone. This means that with EPA, we could potentially achieve better therapeutic outcomes without escalating the drug dosage.
Our findings suggest that incorporating EPA alongside UDCA not only enhances the benefits but could also widen the therapeutic window for patients struggling with liver issues linked to autoimmune disorders. This exciting pharmaco-nutraceutical approach may pave the way for more effective treatments in the future.
Read More
9
Eicosapentaenoic acid aids lupus management
Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity.
Highly relevant to autoimmune research
We sought to understand how dietary fatty acids, specifically eicosapentaenoic acid (EPA), influence autoimmune diseases like lupus. Through our research on both drug-induced and spontaneous mouse models of lupus, we observed that supplementing with EPA significantly eased symptoms associated with the disease.
Some of the notable improvements included reduced autoantibody production and diminished immunocomplex deposits in the kidneys. Our examinations through lipidomic and membrane dynamics analyses revealed that EPA changes the lipid composition and fluidity of B cell membranes. This adjustment appears to restrict the differentiation of B cells into plasma cells that produce harmful autoantibodies.
Overall, our findings indicate a promising new pathway by which fatty acids like EPA can potentially help manage autoimmunity. This suggests that EPA supplementation might serve as a beneficial treatment option for individuals with lupus.
Some of the notable improvements included reduced autoantibody production and diminished immunocomplex deposits in the kidneys. Our examinations through lipidomic and membrane dynamics analyses revealed that EPA changes the lipid composition and fluidity of B cell membranes. This adjustment appears to restrict the differentiation of B cells into plasma cells that produce harmful autoantibodies.
Overall, our findings indicate a promising new pathway by which fatty acids like EPA can potentially help manage autoimmunity. This suggests that EPA supplementation might serve as a beneficial treatment option for individuals with lupus.
Read More
9
Eicosapentaenoic acid's role in arthritis
CCFM1074 Alleviates Collagen-Induced Arthritis in Rats Balancing Treg/Th17 and Modulating the Metabolites and Gut Microbiota.
Relevant but not conclusive effects
We aimed to understand how eicosapentaenoic acid, among other metabolites, plays a role in managing autoimmune disorders like rheumatoid arthritis (RA). We tested two specific strains of probiotics, CCFM1074 and CCFM1075, on rats with collagen-induced arthritis to evaluate their impact on immune responses and gut health.
Our findings showed that CCFM1074 significantly eased symptoms of arthritis, while CCFM1075 did not offer similar benefits. Interestingly, both strains helped reduce inflammation markers, notably lowering plasma levels of IL-6 and decreasing the proportion of harmful Th17 cells. However, CCFM1074 stood out by increasing beneficial Treg cells in the mesenteric lymph nodes.
One of the highlights of our study was the role of eicosapentaenoic acid—a metabolite that was notably regulated by CCFM1074. This fatty acid is linked to improving unsaturated fatty acids metabolism, which may contribute to reducing arthritis symptoms. Additionally, CCFM1074 positively influenced the gut microbiota, altering community structures and enhancing beneficial bacteria populations.
Overall, we observed that eicosapentaenoic acid, alongside other factors, could help alleviate arthritis by promoting a healthier gut environment and balancing immune responses.
Our findings showed that CCFM1074 significantly eased symptoms of arthritis, while CCFM1075 did not offer similar benefits. Interestingly, both strains helped reduce inflammation markers, notably lowering plasma levels of IL-6 and decreasing the proportion of harmful Th17 cells. However, CCFM1074 stood out by increasing beneficial Treg cells in the mesenteric lymph nodes.
One of the highlights of our study was the role of eicosapentaenoic acid—a metabolite that was notably regulated by CCFM1074. This fatty acid is linked to improving unsaturated fatty acids metabolism, which may contribute to reducing arthritis symptoms. Additionally, CCFM1074 positively influenced the gut microbiota, altering community structures and enhancing beneficial bacteria populations.
Overall, we observed that eicosapentaenoic acid, alongside other factors, could help alleviate arthritis by promoting a healthier gut environment and balancing immune responses.
Read More
8
Effect of EPA on autoimmune disorders
Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Direct evidence for EPA benefits
We explored how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences autoimmune disorders, particularly rheumatoid arthritis (RA). Through a rigorous analysis of multiple randomized controlled trials involving 1018 RA patients, we aimed to understand the nuances of EPA's effects on fatty acid distribution, inflammation, and disease activity.
Our findings showed that EPA significantly increased levels of eicosapentaenoic acid and docosahexaenoic acid in the body. More importantly, we observed a reduction in the omega-6 to omega-3 fatty acid ratio and a decrease in triglycerides, which are often elevated in individuals with RA. Additionally, patients experienced fewer tender joints, highlighting EPA’s potential in managing clinical symptoms.
However, while there was a notable reduction in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant. This indicates that while EPA has beneficial effects, its role in significantly lowering inflammation markers remains uncertain.
Overall, this research presents promising evidence that eicosapentaenoic acid can have a positive impact on lipid profiles and joint symptoms for those suffering from RA, but further studies may be needed to fully understand its effectiveness on inflammation markers.
Our findings showed that EPA significantly increased levels of eicosapentaenoic acid and docosahexaenoic acid in the body. More importantly, we observed a reduction in the omega-6 to omega-3 fatty acid ratio and a decrease in triglycerides, which are often elevated in individuals with RA. Additionally, patients experienced fewer tender joints, highlighting EPA’s potential in managing clinical symptoms.
However, while there was a notable reduction in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant. This indicates that while EPA has beneficial effects, its role in significantly lowering inflammation markers remains uncertain.
Overall, this research presents promising evidence that eicosapentaenoic acid can have a positive impact on lipid profiles and joint symptoms for those suffering from RA, but further studies may be needed to fully understand its effectiveness on inflammation markers.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 5 Reviews
9.3
9.5
Highly recommend fish oil
I have tried various fish oil brands, and this one is by far the best. Its effects are noticeable quickly, and I have ordered it again. I highly recommend this product!
9.5
Improved wellbeing
Honestly, I find it excellent. I started using it due to my autoimmune disorder, which caused me health issues. It's helped me feel better and regain my appetite. I will continue to buy it until I am completely healed.
9.5
No allergic reactions
This fish oil has been great for my allergic child with an autoimmune disorder; there were no rashes, and he took it without difficulty.
8.8
Child-friendly supplement
This fish oil has a high omega-3 content and is pleasant to drink. My child enjoys it, and it seems to support him well without any negative reactions.
8.8
Skin improvement
I chose this fish oil after much research and I am very satisfied. It’s pleasant to take and has positively affected my skin, making it more supple and reducing fine wrinkles. I plan to keep ordering it.
